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[Mutations in the thymidylate synthase gene is a major mechanism in the para-aminosalicylic acid resistance of M. tuberculosis].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases - 1 Sept 2007

Zhang Zong-de, Zhao Yan-Lin, Li Zi-Hui, Jia Hong-Yan, Liu Yu-Hong, Chen Xi, Liu Zhong-Quan, Du Bo-Ping, Xing Ai-Ying, Ma Yu

Abstract excerpt

OBJECTIVE: The mechanisms of resistance to para-aminosalicylic acid (PAS) are undefined. In this study, we explored the mechanisms of M. tuberculosis PAS resistance in clinical isolates. METHOD: The whole sequence of thymidylate synthase (thyA) gene encoding thyA genes was sequenced in 51 para-aminosalicylic acid (PAS)-sensitive and 44 resistant M. tuberculosis clinical isolates. RESULTS: Sixteen of 44 resistant...

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PMID: 18070553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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