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Article

Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012.

Antimicrobial agents and chemotherapy - 1 Feb 2015

Zhang Xiaobing, Liu Liguo, Zhang Yan, Dai Guangming, Huang Hairong, Jin Qi

Abstract excerpt

p-Aminosalicylic acid (PAS) is an important compound for treating multidrug-resistant tuberculosis (TB). Previous studies showed that thyA mutations are often related to PAS resistance in clinical isolates. We performed a systematic analysis of isolate genotypes and detected mutations in three folate pathway genes (folC, thyA, and ribD) in 61.1% (127/208) of PAS-resistant isolates, including 11 double mutants....

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Identifiers

PMID: 25421465
DOI: 10.1128/AAC.03695-14
PMCID: PMC4335845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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