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Whole genome sequencing reveals candidate genes involving in PAS resistance in M. Tuberculosis isolated from patients in Thailand.

World journal of microbiology & biotechnology - 7 Dec 2023

Dokladda Kanchana, Billamas Pamaree, Jaitrong Sarinya, Suwanakitti Nattida, Phornsiricharoenphant Worawich, Viratyosin Wasna, Prammananan Therdsak

Abstract excerpt

Para-amino salicylic acid (PAS) was first reported by Lehmann in 1946 and used for tuberculosis treatment. However, due to its adverse effects, it is now used only as a second line anti-tuberculosis drug for treatment of multidrug resistant or extensively drug resistant M. tuberculosis. The structure of PAS is similar to para-amino benzoic acid (pABA), an intermediate metabolite in the folate synthesis pathway....

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Identifiers

PMID: 38057660
DOI: 10.1007/s11274-023-03834-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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