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Rare alternative second line injectable drug resistance markers identified by gene-wise genome wide association in <i>M. tuberculosis</i> with unexplained resistance

2021-11-24

Abstract excerpt

Point mutations in the rrs gene and eis promoter are known to confer resistance to second-line injectable drugs (SLIDs) amikacin (AMK), capreomycin (CAP), and kanamycin (KAN). While mutations in these canonical genes confer a majority of SLID-resistance, alternative mechanisms of resistance are not uncommon and threaten effective treatment decisions when using conventional molecular diagnostics. In total, 1184 c...

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Literature Corpus work
20f9b9b8-2ed6-50f1-9f9b-d9199c7d65ce
DOI
10.1101/2021.11.23.469801
Open publication

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Rare alternative second line injectable drug resistance markers identified by gene-wise genome wide association in <i>M. tuberculosis</i> with unexplained resistanceDOI 10.1101/2021.11.23.469801
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