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DNA Methyltransferase HsdM Induce Drug Resistance on Mycobacterium tuberculosis via Multiple Effects

16 Dec 2021

Abstract excerpt

Besides the genomic variants, epigenetic mechanisms such as DNA methylation also have an effect on drug resistance. This study aimed to investigate the methylomes of totally/extensively drug-resistant M. tuberculosis clinical isolates using the PacBio single-molecule real-time technology. The results showed they were almost the same as the pan-susceptible ones. Genetics and bioinformatics analysis confirmed three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34943756
DOI: 10.3390/antibiotics10121544

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