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Article

Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 May 2009

Mathys Vanessa, Wintjens René, Lefevre Philippe, Bertout Julie, Singhal Amit, Kiass Mehdi, Kurepina Natalia, Wang Xiao-Ming, Mathema Barun, Baulard Alain, Kreiswirth Barry N, Bifani Pablo

Abstract excerpt

The emergence of Mycobacterium tuberculosis resistant to first-line antibiotics has renewed interest in second-line antitubercular agents. Here, we aimed to extend our understanding of the mechanisms underlying para-aminosalicylic acid (PAS) resistance by analysis of six genes of the folate metabolic pathway and biosynthesis of thymine nucleotides (thyA, dfrA, folC, folP1, folP2, and thyX) and three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19237648
DOI: 10.1128/AAC.01197-08
PMCID: PMC2681553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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