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Article

The Assembly-Activating Protein Promotes Stability and Interactions between AAV's Viral Proteins to Nucleate Capsid Assembly.

Cell reports - 8 May 2018

Maurer Anna C, Pacouret Simon, Cepeda Diaz Ana Karla, Blake Jessica, Andres-Mateos Eva, Vandenberghe Luk H

Abstract excerpt

The adeno-associated virus (AAV) vector is a preferred delivery platform for in vivo gene therapy. Natural and engineered variations of the AAV capsid affect a plurality of phenotypes relevant to gene therapy, including vector production and host tropism. Fundamental to these aspects is the mechanism of AAV capsid assembly. Here, the role of the viral co-factor assembly-activating protein (AAP) was evaluated in...

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Identifiers

PMID: 29742436
DOI: 10.1016/j.celrep.2018.04.026
PMCID: PMC5983388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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