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APOBECs orchestrate genomic and epigenomic editing across health and disease

2 Aug 2021

Abstract excerpt

APOBEC proteins can deaminate cytosine residues in DNA and RNA. This can lead to somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective manner. APOBECs function in various cellular compartments and recognize different nucleic acid motifs and structures. They orchestrate a wide array of genomic and epigenomic modifications, thereby affecting various cellular functions positively or...

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PMID: 34353635
DOI: 10.1016/j.tig.2021.07.003

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