Article
The case for transgenerational epigenetic inheritance in humans.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2008
Morgan Daniel K, Whitelaw Emma
Abstract excerpt
Work in the laboratory mouse has identified a group of genes, called metastable epialleles, that are informing us about the mechanisms by which the epigenetic state is established in the embryo. At these alleles, transcriptional activity is dependent on the epigenetic state and this can vary from cell to cell in the one tissue type. The decision to be active or inactive is probabilistic and sensitive to...
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