Article
Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles
23 Dec 2010
Abstract excerpt
Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet predictable epigenetic states across differentiated cells and tissues. At metastable epialleles (MEs), conversely, epigenotype is established stochastically in the early embryo then maintained in differentiated lineages, resulting in dramatic and systemic interindividual variation in epigenetic...