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Article

Epigenome mapping in normal and disease States.

Circulation research - 6 Aug 2010

Maunakea Alika K, Chepelev Iouri, Zhao Keji

Abstract excerpt

Epigenomes are comprised, in part, of all genome-wide chromatin modifications, including DNA methylation and histone modifications. Unlike the genome, epigenomes are dynamic during development and differentiation to establish and maintain cell type-specific gene expression states that underlie cellular identity and function. Chromatin modifications are particularly labile, providing a mechanism for organisms to...

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Identifiers

PMID: 20689072
DOI: 10.1161/CIRCRESAHA.110.222463
PMCID: PMC2917837

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Source receipt: pubmed, retrieved 7 Sept 2026.

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