Article

Pervasive additive and non-additive effects within the HLA region contribute to disease risk in the UK Biobank

2020-05-31

Abstract excerpt

The human leukocyte antigen (HLA) region is one of the most disease-associated regions of the human genome, yet even well-studied alleles in the HLA region have unknown impact on disease. Here, we study the effect of 156 HLA alleles on 677 binary phenotypes for 337,138 individuals in the UK Biobank. We assess HLA allele associations and subsequently use Bayesian Model Averaging for conditional analysis, a) replica...

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Literature Corpus work: d2006a07-63b4-511c-948e-52c888317c64
DOI: 10.1101/2020.05.28.119669

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