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Immune diversity sheds light on missing variation in worldwide genetic diversity panels

26 Oct 2018

Abstract excerpt

Defining worldwide human genetic variation is a critical step to reveal how genome plasticity contributes to disease. Yet, there is currently no metric to assess the representativeness and completeness of current and widely used data on genetic variation. We show here that Human Leukocyte Antigen (HLA) genes can serve as such metric as they are both the most polymorphic and the most studied genetic system. As a...

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PMID: 30365549
DOI: 10.1371/journal.pone.0206512

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