Article

Ionizable Lipids Promote Curvature Remodeling and Altered Fluctuation Dynamics in Endosomal Membranes

2026-08-20

Abstract excerpt

Inefficient endosomal escape is a crucial barrier to intracellular delivery of nucleic acid therapeutics using lipid nanoparticles (LNPs). The use of ionizable lipids (ILs) has significantly improved cargo delivery efficiency, yet the physical basis of their interaction with endosomal membranes and their role in endosomal escape remain unclear. It has been suggested that, as ILs become cationic during endosomal ac...

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Literature Corpus work: 2fdd80da-6f8b-5a12-a9fa-6ad410a403a9
DOI: 10.64898/2026.08.17.745287

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