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Article

Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates

17 Oct 2024

Abstract excerpt

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 facilitate mitophagy by recruiting the autophagy-initiation machinery, and assisting engulfment of damaged mitochondria through binding to ubiquitinated mitochondrial proteins and autophagosomal ATG8 family proteins....

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PMID: 39420095
DOI: 10.1038/s44318-024-00272-5

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