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Article

The dynamics of mutational selection in cutaneous squamous carcinogenesis.

Communications biology - 12 Jan 2026

Skrupskelyte Greta, Fowler Joanna C, Dentro Stefan, Winkler Carine, Abnizova Irina, Beumer Niklas, Sood Roshan, Quarrell Thomas, King Charlotte, Kamarashev Jivko, Guenova Emmanuella, Gerstung Moritz, Hall Benjamin A, Michalik Liliane, Jones Philip H

Abstract excerpt

Identifying the mutant genes that are selected during carcinogenesis is key to identifying candidates for intervention and understanding the processes that promote transformation. Here we applied two selection metrics to study the dynamics of mutational selection in a mouse model of ultraviolet light driven skin carcinogenesis in which multiple synchronous tumors develop in each animal. Sequencing normal skin and...

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Share to Carcinogenesis
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Selection, Genetic

Share to Skin Neoplasms

Share to Tumor Suppressor Protein p53

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Source

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Identifiers

PMID: 41526710
DOI: 10.1038/s42003-025-09406-9
PMCID: PMC12855962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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