Article
Large-scale plasma proteomics comparisons through genetics and disease associations.
Nature - 1 Oct 2023
Eldjarn Grimur Hjorleifsson, Ferkingstad Egil, Lund Sigrun H, Helgason Hannes, Magnusson Olafur Th, Gunnarsdottir Kristbjorg, Olafsdottir Thorunn A, Halldorsson Bjarni V, Olason Pall I, Zink Florian, Gudjonsson Sigurjon A, Sveinbjornsson Gardar, Magnusson Magnus I, Helgason Agnar, Oddsson Asmundur, Halldorsson Gisli H, Magnusson Magnus K, Saevarsdottir Saedis, Eiriksdottir Thjodbjorg, Masson Gisli, Stefansson Hreinn, Jonsdottir Ingileif, Holm Hilma, Rafnar Thorunn, Melsted Pall, Saemundsdottir Jona, Norddahl Gudmundur L, Thorleifsson Gudmar, Ulfarsson Magnus O, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Sulem Patrick, Stefansson Kari
Abstract excerpt
High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge the gap between the genome and diseases. Here we performed association studies of Olink Explore 3072 data generated by the UK Biobank Pharma Proteomics Project1 on plasma samples from more than 50,000 UK Biobank participants with phenotypic and genotypic data,...
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