Article

Comparative studies of genetic and phenotypic associations for 2,168 plasma proteins measured by two affinity-based platforms in 4,000 Chinese adults

2023-12-01

Abstract excerpt

Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured 2,168 plasma proteins in 3,976 Chinese adults using both OLINK and SomaScan platforms and compared their genetic determinants and associations with traits and disease risk. For 1,694 proteins with one-to-one matched reagents, there was a modest...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d0d84b3d-6410-5453-8eb9-3093a2f24f86
DOI: 10.1101/2023.12.01.23299236

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative studies of genetic and phenotypic associations for 2,168 plasma proteins measured by two affinity-based platforms in 4,000 Chinese adultsDOI 10.1101/2023.12.01.23299236Read

Genomic atlas of 7,000 plasma proteins and their associations with diseases and traits in East Asian populationsSemantic proximity Read

An exposome-wide assessment of 6600 SomaScan proteins with non-genetic factors in Chinese adultsSemantic proximity Read

Comprehensive genomic atlas of plasma proteome in the Japanese population: the Nagahama studySemantic proximity Read

Ancestry diversity in the genetic determinants of the human plasma proteome enhances identification of potential drug targetsSemantic proximity Read

Large-scale plasma proteomics comparisons through genetics and disease associations.Semantic proximity Read

An exposome-wide investigation of 2923 Olink proteins with non-genetic factors in Chinese adultsSemantic proximity Read

An Integrated Large-Scale Atlas of Protein Quantitative Trait Loci across Olink and SomaScan platformsSemantic proximity Read

Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanismsSemantic proximity Read

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participantsSemantic proximity Read

Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility.Semantic proximity Read

Mapping biological influences on the human plasma proteome beyond the genomeSemantic proximity Read

Nanoparticle-enriched mass spectrometry proteomics in British South Asians identifies links between genetic variants, plasma protein levels and disease risk.Semantic proximity Read