Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression

27 Sept 2023

Abstract excerpt

BACKGROUND: Glioblastoma is the most common malignant brain tumor in adults. Cellular plasticity and the poorly differentiated features result in a fast relapse of the tumors following treatment. Moreover, the immunosuppressive microenvironment proved to be a major obstacle to immunotherapeutic approaches. Branched-chain amino acid transaminase 1 (BCAT1) was shown to drive the growth of glioblastoma and other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37769206
DOI: 10.1093/neuonc/noad190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppressionPMID 37769206Read ↗

BCAT1 regulates glioblastoma cell plasticity and contributes to immunosuppressionSemantic proximity Read ↗

Epithelial-to-mesenchymal transition activates Bcat1 expression to promote recurrent tumor growthSemantic proximity Read ↗

CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivitySemantic proximity Read ↗

Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediatorsSemantic proximity Read ↗

Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14Semantic proximity Read ↗

MiR-10b-5p Impairs TET2-Mediated Inhibition of PD-L1 Transcription Thus Promoting Immune Evasion and Tumor Progression in GlioblastomaSemantic proximity Read ↗

BCAT1 inhibition affects CD8 <sup>+</sup> T cell activation, exhaustion, and tumoral immunity by altering iron homeostasisSemantic proximity Read ↗

Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype.Semantic proximity Read ↗

Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.Semantic proximity Read ↗

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibitionSemantic proximity Read ↗

A Bi-Specific T Cell-Engaging Antibody Triggers Protective Immune Memory and Glioma Microenvironment Remodeling in Immune Competent Preclinical ModelsSemantic proximity Read ↗

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.