Article

Epithelial-to-mesenchymal transition activates Bcat1 expression to promote recurrent tumor growth

2020-12-09

Abstract excerpt

Branched-chain amino acid metabolism has emerged as a crucial regulator of tumor proliferation. In particular, the branched-chain amino acid transaminase 1 (BCAT1), which catalyzes the conversion of branched-chain amino acids to α-keto acids in the cytoplasm, has been identified as a promising therapeutic target for several different cancer types, including gliomas and leukemias. BCAT1 expression has also been ass...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bc7abf5-fef0-596a-9585-ce8a73a9a49f
DOI: 10.1101/2020.12.08.416479

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epithelial-to-mesenchymal transition activates Bcat1 expression to promote recurrent tumor growthDOI 10.1101/2020.12.08.416479Read

Multi-omics analysis identifies BCAT2 as a potential pan-cancer biomarker for tumor progression and immune microenvironment modulationSemantic proximity Read

BCAT1 regulates glioblastoma cell plasticity and contributes to immunosuppressionSemantic proximity Read

Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppressionSemantic proximity Read

The MALAT1-breast cancer interplay: insights and implicationsSemantic proximity Read

Identify BCAT1 plays an oncogenic role and promotes EMT in KIRC via single cell RNA-seq and experimentSemantic proximity Read

CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivitySemantic proximity Read

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.Semantic proximity Read

GALNT1 Expression Is Associated with Angiogenesis and Is a Prognostic Biomarker for Breast Cancer in Adolescents and Young Adults (AYA)Semantic proximity Read

Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype.Semantic proximity Read

BCAT1 Promotes Lung Adenocarcinoma Progression Through Enhanced Mitochondrial Respiration and NF-κB Pathway ActivationSemantic proximity Read

BCAT1 Overexpression Promotes Proliferation, Invasion, and Wnt Signaling in Non-Small Cell Lung CancersSemantic proximity Read

The Influence of the Amino Acid Transporter LAT1 on Patient Prognosis and the Relationships between Tumor Immunometabolic and Proliferative Features Depend on Menopausal Status in Breast CancerSemantic proximity Read