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Article

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.

Nature - 16 Nov 2017

Raffel Simon, Falcone Mattia, Kneisel Niclas, Hansson Jenny, Wang Wei, Lutz Christoph, Bullinger Lars, Poschet Gernot, Nonnenmacher Yannic, Barnert Andrea, Bahr Carsten, Zeisberger Petra, Przybylla Adriana, Sohn Markus, Tönjes Martje, Erez Ayelet, Adler Lital, Jensen Patrizia, Scholl Claudia, Fröhling Stefan, Cocciardi Sibylle, Wuchter Patrick, Thiede Christian, Flörcken Anne, Westermann Jörg, Ehninger Gerhard, Lichter Peter, Hiller Karsten, Hell Rüdiger, Herrmann Carl, Ho Anthony D, Krijgsveld Jeroen, Radlwimmer Bernhard, Trumpp Andreas

Abstract excerpt

The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely uncertain. Here, by performing high-resolution proteomic analysis of human acute myeloid leukaemia (AML) stem-cell and non-stem-cell populations, we find the BCAA pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29144447
DOI: 10.1038/nature24294

Genes

BCAT1
EGLN1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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