Article

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

2023-11-16

Abstract excerpt

The glioblastoma microenvironment is enriched in immunosuppressive factors that potently interfere with the function of cytotoxic T lymphocytes. Cancer cells can directly impact the immune system, but the mechanisms driving these interactions are not completely clear. Here we demonstrate that the polyamine metabolite spermidine is elevated in the glioblastoma tumor microenvironment. Exogenous administration of spe...

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Literature Corpus work: 2dd54f9d-b29f-5b47-9b7e-d7ab0bb633d5
DOI: 10.1101/2023.11.14.567048

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Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibitionDOI 10.1101/2023.11.14.567048Read

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