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Article

Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype.

EMBO reports - 1 Dec 2017

Silva Lidia Santos, Poschet Gernot, Nonnenmacher Yannic, Becker Holger M, Sapcariu Sean, Gaupel Ann-Christin, Schlotter Magdalena, Wu Yonghe, Kneisel Niclas, Seiffert Martina, Hell Rüdiger, Hiller Karsten, Lichter Peter, Radlwimmer Bernhard

Abstract excerpt

Elevated amino acid catabolism is common to many cancers. Here, we show that glioblastoma are excreting large amounts of branched-chain ketoacids (BCKAs), metabolites of branched-chain amino acid (BCAA) catabolism. We show that efflux of BCKAs, as well as pyruvate, is mediated by the monocarboxylate transporter 1 (MCT1) in glioblastoma. MCT1 locates in close proximity to BCKA-generating branched-chain amino acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29066459
DOI: 10.15252/embr.201744154
PMCID: PMC5709768

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