Article

BCAT1 inhibition affects CD8 <sup>+</sup> T cell activation, exhaustion, and tumoral immunity by altering iron homeostasis

2023-02-26

Abstract excerpt

<h4>ABSTRACT</h4> The present study explores the role of the cytosolic branched chain amino acid aminotransferase (BCAT1) in CD8 + T cell activation, in general, and tumor immunity, in particular, and identifies a non-canonical function of the protein in iron homeostasis. Pharmacologic inhibition of BCAT1 using the novel drug ERG245 abrogates the effector functions of CD8 + T cells in vitro and metabolically re...

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Literature Corpus work: 9a42d0f6-deea-5d58-9966-beb3484a5f70
DOI: 10.1101/2023.02.25.530034

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BCAT1 inhibition affects CD8 <sup>+</sup> T cell activation, exhaustion, and tumoral immunity by altering iron homeostasisDOI 10.1101/2023.02.25.530034Read

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