Article

Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators

2020-03-25

Abstract excerpt

Immunosuppression of unknown etiology is a hallmark feature of glioblastoma (GBM) and is characterized by decreased CD4 T cell counts and down regulation of MHC class II expression on peripheral blood monocytes in patients. This immunosuppression is a critical barrier to the successful development of immunotherapies for GBM. We recapitulated the immunosuppression observed in GBM patients in the C57BL/6 mouse and i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06d2341b-9bf2-58b9-a4a0-db4c3c7c896c
DOI: 10.1101/2020.03.24.006825

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediatorsDOI 10.1101/2020.03.24.006825Read

Cellular architecture of human brain metastases.Semantic proximity Read

Programs, origins and immunomodulatory functions of myeloid cells in glioma.Semantic proximity Read

The Dynamics of Interactions Among Immune and Glioblastoma Cells.Semantic proximity Read

Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical DevelopmentsSemantic proximity Read

Immune Cell Interplay in the Fight Against GBMSemantic proximity Read

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastomaSemantic proximity Read

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapySemantic proximity Read

Differential effects of PD-1 and PD-L1 immune checkpoint inhibition on cognition and anxiety-like behavior through γδT cells and tumor–dependent neuroinflammationSemantic proximity Read

Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulationSemantic proximity Read

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironmentSemantic proximity Read

BBB dysfunction drives neurotoxic myeloid cells in glioblastoma and Alzheimer’s diseaseSemantic proximity Read

Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles.Semantic proximity Read