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Article

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants.

Journal of clinical microbiology - 24 Oct 2023

Zhang Xiaomei, Lam Connie, Martinez Elena, Sim Eby, Crighton Taryn, Marais Ben J, Sintchenko Vitali

Abstract excerpt

Minority variants of Mycobacterium tuberculosis harboring mutations conferring resistance can become dominant populations during tuberculosis (TB) treatment, leading to treatment failure. Our understanding of drug-resistant within-host subpopulations and the frequency of resistance-conferring mutations in minority variants remains limited. M. tuberculosis sequences recovered from liquid cultures of...

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Identifiers

PMID: 37750734
DOI: 10.1128/jcm.00485-23
PMCID: PMC10595065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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