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Article

In-host population dynamics of Mycobacterium tuberculosis complex during active disease.

eLife - 1 Feb 2021

Vargas Roger, Freschi Luca, Marin Maximillian, Epperson L Elaine, Smith Melissa, Oussenko Irina, Durbin David, Strong Michael, Salfinger Max, Farhat Maha Reda

Abstract excerpt

Tuberculosis (TB) is a leading cause of death globally. Understanding the population dynamics of TB's causative agent Mycobacterium tuberculosis complex (Mtbc) in-host is vital for understanding the efficacy of antibiotic treatment. We use longitudinally collected clinical Mtbc isolates that underwent Whole-Genome Sequencing from the sputa of 200 patients to investigate Mtbc diversity during the course of active...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33522489
DOI: 10.7554/eLife.61805
PMCID: PMC7884073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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