Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cryptic Microheteroresistance Explains Mycobacterium tuberculosis Phenotypic Resistance

14 Jun 2017

Abstract excerpt

RATIONALE: Minority drug-resistant Mycobacterium tuberculosis subpopulations can be associated with phenotypic resistance but are poorly detected by Sanger sequencing or commercial molecular diagnostic assays. OBJECTIVES: To determine the role of targeted next-generation sequencing in resolving these minor variant subpopulations. METHODS: We used single molecule overlapping reads (SMOR), a targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infectious Diseases and Tuberculosis
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28614668
DOI: 10.1164/rccm.201703-0556oc

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cryptic Microheteroresistance Explains Mycobacterium tuberculosis Phenotypic ResistancePMID 28614668Read ↗

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants.Semantic proximity Read ↗

Mixed-strain infection and heteroresistance in drug-resistant tuberculosis: insights from a whole-genome sequencing pilotSemantic proximity Read ↗

Cryptic Resistance Mutations Associated With Misdiagnoses of Multidrug-Resistant TuberculosisSemantic proximity Read ↗

Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing.Semantic proximity Read ↗

Challenging the gold standard: critical limitations in clinical detection of drug-resistant tuberculosisSemantic proximity Read ↗

Bacterial heteroresistance mechanisms, dynamics, and emerging diagnostic approaches.Semantic proximity Read ↗

Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment.Semantic proximity Read ↗

Dissecting rifampicin heteroresistance in Mycobacterium tuberculosis: integrating whole-genome sequencing with phenotypic and clonal validation.Semantic proximity Read ↗

Challenging the gold standard: the limitations of molecular assays for detection of Mycobacterium tuberculosis heteroresistance.Semantic proximity Read ↗

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.Semantic proximity Read ↗

Direct transmission of within-host Mycobacterium tuberculosis diversity to secondary cases can lead to variable between-host heterogeneity without de novo mutation: A genomic investigationSemantic proximity Read ↗

Deep sequencing reveals subpopulation dynamics associated with treatment failure in a rare non-tuberculous mycobacterial infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.