Article
Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing.
PloS one - 1 Jan 2015
Colman Rebecca E, Schupp James M, Hicks Nathan D, Smith David E, Buchhagen Jordan L, Valafar Faramarz, Crudu Valeriu, Romancenco Elena, Noroc Ecaterina, Jackson Lynn, Catanzaro Donald G, Rodwell Timothy C, Catanzaro Antonino, Keim Paul, Engelthaler David M
Abstract excerpt
Undetected and untreated, low-levels of drug resistant (DR) subpopulations in clinical Mycobacterium tuberculosis (Mtb) infections may lead to development of DR-tuberculosis, potentially resulting in treatment failure. Current phenotypic DR susceptibility testing has a theoretical potential for 1% sensitivity, is not quantitative, and requires several weeks to complete. The use of "single molecule-overlapping...
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