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Mixed-strain infection and heteroresistance in drug-resistant tuberculosis: insights from a whole-genome sequencing pilot

6 Aug 2026

Abstract excerpt

Background Mixed-strain Mycobacterium tuberculosis ( M. tuberculosis; Mtb) infections and heteroresistance are increasingly recognized as under-detected contributors to drug resistance dynamics. In high-burden rural settings such as the Eastern Cape, these genomic features may reflect both within-host diversity and ongoing transmission. However, their epidemiological and clinical implications remain incompletely...

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PMID: 42625812
DOI: 10.3389/fepid.2026.1813571

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