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Subpopulations in clinical samples of <i>M. tuberculosis</i> can give rise to rifampicin resistance and shed light on how resistance is acquired

2025-04-09

Abstract excerpt

<h4>Objectives</h4> Whole genome sequencing (WGS) has become a key tool for diagnosing Mycobacterium tuberculosis (M. tuberculosis) infections, but discrepancies between genotypic and phenotypic drug susceptibility testing can hinder effective treatment and surveillance. This study investigates the impact of resistant subpopulations and compensatory mutations in WGS-based rifampicin resistance prediction. <h4>M...

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Literature Corpus work
19fad560-98cc-51f4-9ce4-c52379c8d1c6
DOI
10.1101/2025.04.09.647945
Open publication

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