Article
The glucocorticoid receptor gene and its association to metabolic syndrome.
Obesity research - 1 Oct 2002
Rosmond Roland
Abstract excerpt
In recent decades, there has been an increasing interest in the role of endogenous glucocorticoids such as cortisol in the pathogenesis of metabolic syndrome. Studies in humans have suggested a positive association between obesity, hypertension, and insulin resistance, with alleles at the glucocorticoid receptor (GR) gene. For instance, the BclI polymorphism within the intron upstream of GR exon 2 has been...
Topics
- Alleles
- Female
- Glucocorticoids
- Humans
- Male
- Metabolic Syndrome
- Mutation
- Obesity
- Receptors, Glucocorticoid