Article
Glucocorticoid receptor polymorphism in obesity and glucose homeostasis.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Jan 2000
Majer-Łobodzińska Agnieszka, Adamiec-Mroczek Joanna
Abstract excerpt
Glucocorticoid receptor (GR) activity plays a significant role in the etiology of obesity and is essential for glucose homeostasis, the development of hyperinsulinaemia and subsequent increased fat deposition. Several polymorphisms in the GR gene have been described, and at least three of them seem to be associated with altered glucocorticoid sensitivity and changes in glucose homeostasis, and other metabolic...
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