Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucocorticoid receptor haplotype and metabolic syndrome: the Lifelines cohort study.

European journal of endocrinology - 1 Dec 2016

Wester Vincent L, Koper Jan W, van den Akker Erica L T, Franco Oscar H, Stolk Ronald P, van Rossum Elisabeth F C

Abstract excerpt

OBJECTIVE: An excess of glucocorticoids (Cushing's syndrome) is associated with metabolic syndrome (MetS) features. Several single-nucleotide polymorphisms (SNPs) in the glucocorticoid receptor (GR) gene influence sensitivity to glucocorticoids and have been associated with aspects of MetS. However, results are inconsistent, perhaps due to the heterogeneity of the studied populations and limited samples....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Metabolic Syndrome

Share to Netherlands

Share to Polymorphism, Single Nucleotide

Share to Population Surveillance

Share to Receptors, Glucocorticoid

Source

Identifiers

PMID: 27634941
DOI: 10.1530/EJE-16-0534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoid receptor haplotype and metabolic syndrome: the Lifelines cohort study.PMID 27634941Read ↗

Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease.Semantic proximity Read ↗

Corticosteroid receptor genetic polymorphisms and stress responsivity.Semantic proximity Read ↗

Associations between polymorphisms in the glucocorticoid-receptor gene and cardiovascular risk factors in a Chinese population.Semantic proximity Read ↗

HPA axis dysregulation, NR3C1 polymorphisms and glucocorticoid receptor isoforms imbalance in metabolic syndrome.Semantic proximity Read ↗

Genetic glucocorticoid receptor variants differ between ethnic groups but do not explain variation in age of diabetes onset, metabolic and inflammation parameters in patients with type 2 diabetes.Semantic proximity Read ↗

Long-term glucocorticoid concentrations as a risk factor for childhood obesity and adverse body-fat distribution.Semantic proximity Read ↗

[Association of the structure of the glucocorticoid receptor and single nucleotide NR3C1 gene polymorphisms with metabolic disorders].Semantic proximity Read ↗

The glucocorticoid receptor gene and its association to metabolic syndrome.Semantic proximity Read ↗

The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness.Semantic proximity Read ↗

The clinical significance of the glucocorticoid receptors: Genetics and epigeneticsSemantic proximity Read ↗

Human glucocorticoid receptor isoform β: recent understanding of its potential implications in physiology and pathophysiologySemantic proximity Read ↗

Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.