Article
Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease.
Steroids - 1 Dec 2014
Koper Jan W, van Rossum Elisabeth F C, van den Akker Erica L T
Abstract excerpt
Cortisol is involved in many physiological processes, including immunosuppressive and anti-inflammatory actions, and therefore cortisol and its synthetic analogs are widely used to treat a large number of diseases. In glucocorticoid treatment, a large variability of clinical responses is observed. This variability may, in part, be ascribed to genetic variation in the glucocorticoid receptor (GR) gene. In this...
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