Article
Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset.
European journal of endocrinology - 1 Aug 2001
Ye W Z, Reis A F, Dubois-Laforgue D, Bellanné-Chantelot C, Timsit J, Velho G
Abstract excerpt
OBJECTIVE: Allelic variations in the vitamin D receptor (VDR) gene were reported to modulate insulin secretion in response to glucose. VDR was investigated as a candidate gene for type 2 diabetes mellitus (T2DM). METHOD: Four single nucleotide polymorphisms (SNPs) in intron 8 (BsmI, Tru9I, ApaI) and exon 9 (TaqI) of the VDR gene were examined in 309 unrelated French subjects with T2DM and 143 controls. RESULTS:...
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