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Article

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

Genes & development - 1 Sept 2009

Martínez Paula, Thanasoula Maria, Muñoz Purificación, Liao Chunyan, Tejera Agueda, McNees Carolyn, Flores Juana M, Fernández-Capetillo Oscar, Tarsounas Madalena, Blasco Maria A

Abstract excerpt

The telomere repeat-binding factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease has remained elusive. Here, we report on cells and mice conditionally deleted for TRF1. TRF1-deleted mouse embryonic fibroblasts (MEFs) show rapid induction of senescence, which is concomitant with abundant telomeric gamma-H2AX foci and activation of the...

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Identifiers

PMID: 19679647
DOI: 10.1101/gad.543509
PMCID: PMC2751970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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