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Article

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003

Kannan Karuppiah, Sharpless Norman E, Xu Jin, O'Hagan Ronan C, Bosenberg Marcus, Chin Lynda

Abstract excerpt

Epidemiological studies support a link between melanoma risk and UV exposure early in life, yet the molecular targets of UV's mutagenic actions are not known. By using well characterized murine models of melanoma, we provide genetic and molecular evidence that identifies components of the Rb pathway as the principal targets of UV mutagenesis in murine melanoma development. In a melanoma model driven by H-RAS...

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Identifiers

PMID: 12538879
DOI: 10.1073/pnas.0336397100
PMCID: PMC298754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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