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Article

Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53.

Nature - 24 Jul 2014

Viros Amaya, Sanchez-Laorden Berta, Pedersen Malin, Furney Simon J, Rae Joel, Hogan Kate, Ejiama Sarah, Girotti Maria Romina, Cook Martin, Dhomen Nathalie, Marais Richard

Abstract excerpt

Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the molecular mechanisms by which UVR drives melanomagenesis remain unclear. The most common somatic mutation in melanoma is a V600E substitution in BRAF, which is an early event. To investigate how UVR accelerates...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24919155
DOI: 10.1038/nature13298
PMCID: PMC4112218

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24919155-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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