Article
Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.
Science (New York, N.Y.) - 29 Sept 2017
Chiba Kunitoshi, Lorbeer Franziska K, Shain A Hunter, McSwiggen David T, Schruf Eva, Oh Areum, Ryu Jekwan, Darzacq Xavier, Bastian Boris C, Hockemeyer Dirk
Abstract excerpt
TERT promoter mutations (TPMs) are the most common noncoding mutations in cancer. The timing and consequences of TPMs have not been fully established. Here, we show that TPMs acquired at the transition from benign nevus to malignant melanoma do not support telomere maintenance. In vitro experiments revealed that TPMs do not prevent telomere attrition, resulting in cells with critically short and unprotected...
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