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Telomere length, telomerase reverse transcriptase promoter mutations, and melanoma risk.

Genes, chromosomes & cancer - 1 Nov 2018

Rachakonda Sivaramakrishna, Kong Haiying, Srinivas Nalini, Garcia-Casado Zaida, Requena Celia, Fallah Mahdi, Heidenreich Barbara, Planelles Dolores, Traves Victor, Schadendorf Dirk, Nagore Eduardo, Kumar Rajiv

Abstract excerpt

Telomere repeats at chromosomal ends, critical for genomic integrity, undergo age-dependent attrition and telomere length has been associated with different disorders including cancers. In this study, based on 1469 patients and 1158 healthy controls, we show a statistically significant (P = 6 × 10-10 ) association between increased telomere length and melanoma risk. Mendelian randomization, using 5 telomere...

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PMID: 30203894
DOI: 10.1002/gcc.22669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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