Article

UVB mutagenesis differs in <i>NRAS</i> - and <i>BRAF</i> -mutant mouse models of melanoma

2019-09-25

Abstract excerpt

<h4>ABSTRACT</h4> BRAF -mutant melanomas are more likely than NRAS -mutant melanomas to arise in anatomical locations protected from chronic sun damage. We hypothesized that this discrepancy in tumor location is a consequence of the differential sensitivity of BRAF and NRAS -mutant melanocytes to ultraviolet light (UV)-mediated carcinogenesis. We tested this hypothesis by comparing the mutagenic consequences o...

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Literature Corpus work: fbf1983c-ff89-59d0-9dcb-e385e05d8d84
DOI: 10.1101/778449

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