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Article

Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum C

4 Jan 2013

Abstract excerpt

Xeroderma pigmentosum (XP), a UV-sensitivity syndrome characterized by skin hyperpigmentation, premature aging, and increased skin cancer, is caused by defects in the nucleotide excision repair (NER) pathway. XP shares phenotypical characteristics with telomere-associated diseases like Dyskeratosis congenita and mouse models with dysfunctional telomeres, including mice deficient for telomerase (Terc(-/-) mice)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23288511
DOI: 10.1158/0008-5472.can-12-3125

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