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The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus.

Molecular neurodegeneration - 19 Sept 2023

Lee Jun Yup, Harney Dylan J, Teo Jonathan D, Kwok John B, Sutherland Greg T, Larance Mark, Don Anthony S

Abstract excerpt

BACKGROUND: The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention and treatment. This study aimed to determine how ageing and major genetic risk factors for dementia affect the hippocampal proteome and lipidome of...

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Identifiers

PMID: 37726834
DOI: 10.1186/s13024-023-00650-3
PMCID: PMC10510131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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