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Article

CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

Experimental gerontology - 1 Apr 2017

Fardo David W, Katsumata Yuriko, Kauwe John S K, Deming Yuetiva, Harari Oscar, Cruchaga Carlos, Nelson Peter T

Abstract excerpt

OBJECTIVE: Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS: Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n=237) data, combining both multiplexed proteomics CSF and genotype data, were used to assess...

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Identifiers

PMID: 28189700
DOI: 10.1016/j.exger.2017.01.025
PMCID: PMC5389672

Genes

GRN
AXL
ABCC9
APOE
CLU
MAPT
TNF

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