Compilation of all known protein changes in the human Alzheimer’s disease brain

Abstract excerpt

Proteomic studies of human Alzheimer’s disease brain tissue have exceptional potential to identify protein changes that drive disease and to identify new drug targets. Here, we detail a combined analysis of 38 published Alzheimer’s disease proteomic studies, generating a comprehensive map of protein changes in human brain tissue across thirteen brain regions, three disease stages (preclinical Alzheimer’s disease,...

Topics

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• Advanced Proteomics Techniques and Applications
• Alzheimer Disease
• Alzheimer's disease research and treatments
• Bioinformatics and Genomic Networks
• Dementia and Cognitive Impairment Research
• Peptidase Inhibition and Analysis
• Protein Hydrolysis and Bioactive Peptides
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

9773c103-233a-5ab8-858d-f1da8e8df623

DOI

10.1101/2023.04.13.536828