Article

Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation

2026-03-28

Abstract excerpt

Variants in TMEM106B and GRN , which encode lysosomal proteins, interact through unknown mechanisms to increase the risk of age-related cognitive decline and neurodegeneration. Here, we show that these variants converge on a single molecular intermediate: the cleaved intra-lysosomal fibril core of TMEM106B, a precursor to amyloid fibrils that accumulate in the aging brain. A protein-coding TMEM106B risk variant...

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Literature Corpus work: 5a2c2aa8-5709-558a-9f54-a0ff25948c35
DOI: 10.64898/2026.03.26.714634

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