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Article

TMEM106B expression is reduced in Alzheimer’s disease brains

31 Mar 2014

Abstract excerpt

INTRODUCTION: TMEM106B is a transmembrane glycoprotein of unknown function located within endosome/lysosome compartments expressed ubiquitously in various cell types. Previously, the genome-wide association study (GWAS) identified a significant association of TMEM106B single nucleotide polymorphisms (SNPs) with development of frontotemporal lobar degeneration with ubiquitinated TAR DNA-binding protein-43...

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PMID: 24684749
DOI: 10.1186/alzrt247

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TMEM106B expression is reduced in Alzheimer’s disease brainsPMID 24684749Read ↗

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Semantic proximity Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionSemantic proximity Read ↗

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.Semantic proximity Read ↗

The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Semantic proximity Read ↗

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Semantic proximity Read ↗

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read ↗

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Semantic proximity Read ↗

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Semantic proximity Read ↗

Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human DiseaseSemantic proximity Read ↗

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.Semantic proximity Read ↗

TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.Semantic proximity Read ↗

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