Article

<i>TMEM106B</i> haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain

2026-08-12

Abstract excerpt

<h4>ABSTRACT</h4> A central challenge in post-GWAS biology is determining how inherited variation within disease-associated loci shapes molecular mechanisms and clinical phenotypes. Here, we examined four previously identified TMEM106B haplotypes (T1-T4), defined by distinct combinations of coding, structural and regulatory variants. We integrated transcriptomic, proteomic, and neuropathological data from 1,299...

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Literature Corpus work: d138a1e3-ea8b-56cb-bac9-cf483512b68a
DOI: 10.64898/2026.08.11.26359568

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