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Article

Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM.

Cellular and molecular life sciences : CMLS - 20 Sept 2023

Belapurkar Vivek, Mahadeva Swamy H S, Singh Nivedita, Kedia Shekhar, Setty Subba Rao Gangi, Jose Mini, Nair Deepak

Abstract excerpt

Recently, the localization of amyloid precursor protein (APP) into reversible nanoscale supramolecular assembly or "nanodomains" has been highlighted as crucial towards understanding the onset of the molecular pathology of Alzheimer's disease (AD). Surface expression of APP is regulated by proteins interacting with it, controlling its retention and lateral trafficking on the synaptic membrane. Here, we evaluated...

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Identifiers

PMID: 37726569
DOI: 10.1007/s00018-023-04939-w
PMCID: PMC11072284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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